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Cell Reports Methods • Vol 5 • No 7
Self-supervised learning for generalizable particle picking in cryo-EM micrographs
2025
We present cryoelectron microscopy masked autoencoder (cryo-EMMAE), a self-supervised method designed to overcome the need for manually annotated cryo-EM data. cryo-EMMAE leverages the representation space of a masked autoencoder to pick particle pixels throu…
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Artificial Intelligence

Intelligence of machines

Artificial intelligence (AI) is the capability of computational systems to perform tasks typically associated with human intelligence, such as learning, reasoning, problem-solving, perception, and decision-making. It is a field of research in computer science that develops and studies methods and software that enable machines to perceive their environment and use learning and intelligence to take actions that maximize their chances of achieving defined goals.

High-profile applications of AI include advanced web search engines (e.g., Google Search); recommendation systems (used by YouTube, Amazon, and Netflix); virtual assistants (e.g., Google Assistant, Siri, and Alexa); autonomous vehicles (e.g., Waymo); generative and creative tools (e.g.

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Cell Reports Methods • Vol 5 • No 7
Self-supervised learning for generalizable particle picking in cryo-EM micrographs
2025
We present cryoelectron microscopy masked autoencoder (cryo-EMMAE), a self-supervised method designed to overcome the need for manually annotated cryo-EM data. cryo-EMMAE leverages the representation space of a masked autoencoder to pick particle pixels through clustering of the MAE latent representation. Evaluation across different EMPIAR datasets demonstrates that cryo-EMMAE outperforms state-of-the-art supervised methods in terms of generalization capabilities. Importantly, our method showcases consistent perfo…
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