Point-of-Care Testing Using Three Dimensional Optical Biosensor Based on Microfluidic Technology Article Swipe
Chunxiu Liu
,
Haoyuan Cai
,
Jian Jia
,
Tianyang Cao
,
Tong Li
,
Tianjun Ma
,
Chang Liu
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4236/jbm.2016.412009
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4236/jbm.2016.412009
We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magnetic nanoparticles on chip and total internal reflection imaging (TIRI) technology permits the sensitive and rapid detection of hs-CRP (high-sensitivity C-reactive protein). The whole test was complete within 10 min using “all in one step” assay with a limit of detection of 0.1 ng/mL hs-CRP. The measuring range for hs-CRP could be extended to 10 ng/mL. The chip can also be used to detect more parameters in blood samples.
Related Topics To Compare & Contrast
Concepts
Miniaturization
Point of care
Detection limit
Point-of-care testing
Microfluidics
Chip
Lab-on-a-chip
Sensitivity (control systems)
Biosensor
Microfluidic chip
Nanotechnology
Biomedical engineering
Chromatography
Materials science
Chemistry
Computer science
Electronic engineering
Medicine
Engineering
Pathology
Telecommunications
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4236/jbm.2016.412009
- https://www.scirp.org/journal/PaperDownload.aspx?paperID=72446
- OA Status
- diamond
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2557655776
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