main webpage W Topic Dehydration Dehydration promotes intracellular lipid synthesis and accumulation 2025 Abstract Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration directly regulates lipid synthesis is unknown, which is the focus of this study. We foun… Article Open Dehydration Open Article Page

Dehydration

Deficit of total body water In physiology, dehydration is a lack of total body water, with an accompanying disruption of metabolic processes. It occurs when free water loss exceeds free water intake, usually due to exercise, disease, or high environmental temperature. Mild dehydration can also be caused by immersion diuresis, which may increase risk of decompression sickness in divers. Most people can tolerate a 3-4% decrease in total body water without difficulty or adverse health effects. A 5-8% decrease can cause fatigue and dizziness. Loss of over 10% of total body water can cause physical and mental deterioration, accompanied by severe thirst. Death occurs at a loss of between 15 and 25% of the body water. Critical Symbolic Virtual Narrative Open Dehydration Open Article Page

Exploring foci of: Dehydration promotes intracellular lipid synthesis and accumulation 2025 Abstract Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration directly regulates lipid synthesis is unknown, which is the focus of this study. We found that dehydration stress decreases cellular oxygen consumption, increases intracellular lipid synthesis, and favors glutamine oxidation as a carbon precursor for lipid synthesis via remodeling mitochondrial metabolism. These findings provide a mechanism where… Open Article Page

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Explore Dehydration W Topic Dehydration Dehydration promotes intracellular lipid synthesis and accumulation 2025 Abstract Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration directly regulates lipid synthesis is unknown, which is the focus of this study. We foun… Article Critical Symbolic Virtual Narrative Open Dehydration Open Article Page