Diffuse midline glioma (DMG), H3K27 altered , previously called diffuse
intrinsic pontine glioma (DIPG) is a fatal tumour that arises in the
brainstem, most commonly in the pons or thalamus. DMG is believed to be caused
by genetic mutations that cause epigenetic changes in cells of the developing
nervous system, resulting in a failure of the cells to properly differentiate.
Currently, the standard of care is fractionated external beam radiotherapy, as
the tumour location precludes surgery and chemotherapy has shown to be
ineffective. However, the estimated survival post-diagnosis remains only 9–15
months.
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