Additional file 1 of Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning Article Swipe

View

Alexander Neumann , Olena Ohlei , Fahri Küçükali , Isabelle Bos , Jigyasha Timsina , Stephanie J. B. Vos , Dmitry Prokopenko , Betty M. Tijms , Ulf Andréasson , Kaj Blennow , Rik Vandenberghe , Philip Scheltens , Charlotte E. Teunissen , Sebastiaan Engelborghs , Giovanni B. Frisoni , Oliver Blin , Jill Richardson , Régis Bordet , Alberto Lleó , Daniel Alcolea , Julius Popp , Thomas W. Marsh , Priyanka Gorijala , Christopher Clark , Gwendoline Peyratout , Pablo Martínez‐Lage , Mikel Tainta , Richard Dobson , Cristina Legido‐Quigley , Christine Van Broeckhoven , Rudolph E. Tanzi , Mara ten Kate , Christina M. Lill , Frederik Barkhof , Carlos Cruchaga , Simon Lovestone , Johannes Streffer , Henrik Zetterberg , Pieter Jelle Visser , Kristel Sleegers , Lars Bertram ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.6084/m9.figshare.24248104

Additional file 1: Table S1. Participant Characteristics CSF Biomarker Sample. Table S2. Participant Characteristics GWAS Discovery Sample. Table S3. Participant Characteristics GWAS Replication Sample. Table S4. Local heritability and variance explained. Table S5. PCA loadings (individual cohorts). Table S6. Sex differences in CSF biomarker PCs and associations with Alzheimer’s disease. Table S7. Comparison of PCA-based GWAS results vs. single biomarker GWAS results. Table S8. Comparison of meta-analysis results using fixed effect vs. random effects models. Table S9a. PC5 top hits in meta-analysis split by discovery datasets. Table S9b. PC5 non-AD synaptic functioning replication and meta-analysis for top SNPs (p < 10E-3). Table S9c. SNP-based association results in Knight-ADRC dataset in GRIN2D region (bold font highlights nominally significant signals). Table S10. TWAS Fine-mapping analyses. Table S11. Gene-set enrichment analyses based on PC-based GWAS (top 20 gene sets [by P-value] are shown; bold font = significant after FDR [0.05]).

Related Topics To Compare & Contrast

Genome-Wide Association Study

Concepts

Multivariate statistics Biomarker Disease Genome-wide association study Multivariate analysis Oncology Medicine Internal medicine Neuroscience Biology Computer science Genetics Machine learning Gene Single-nucleotide polymorphism Genotype

Metadata

Type: dataset
Language: en
Landing Page: https://doi.org/10.6084/m9.figshare.24248104
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4394305205

All OpenAlex metadata

Raw OpenAlex JSON

No additional metadata available.