main webpage W Topic Epigenetics Molecular Cancer • Vol 22 • No 1 Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy 2023 Abstract Background Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody treatment, has been of tremendous success in clinical practice. However, the low clinical response rate and lack of biomarkers for prediction of the immune response l… Article Open Epigenetics Open Article Page

Epigenetics

Study of DNA modifications that do not change its sequence In biology, epigenetics are stable heritable traits that cannot be explained by changes in DNA sequence, and the study of a type of stable change in cell function (known as a mark ) that does not involve a change to the DNA sequence. The Greek prefix epi- (ἐπι- "over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. Such effects on cellular and physiological phenotypic traits may result from environmental factors, or be part of normal development. They can lead to cancer. Critical Symbolic Virtual Narrative Open Epigenetics Open Article Page

Exploring foci of: Molecular Cancer • Vol 22 • No 1 Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy 2023 Abstract Background Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody treatment, has been of tremendous success in clinical practice. However, the low clinical response rate and lack of biomarkers for prediction of the immune response limit the clinical application of anti-PD-1 immunotherapy. Our recent work showed that a combination of low-dose decitabine and PD-1-ab significantly improved the complete response (CR) rate of cHL patients from 32 to 71%, which indicates that there is a signif… Open Article Page

Click Epigenetics Vs: Biology Cancer Immunotherapy T Cell Immune System Immunology Cell (Biology) Gene Expression In Vitro Open Article Page

Explore Epigenetics W Topic Epigenetics Molecular Cancer • Vol 22 • No 1 Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy 2023 Abstract Background Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody treatment, has been of tremendous success in clinical practice. However, the low clinical response rate and lack of biomarkers for prediction of the immune response l… Article Critical Symbolic Virtual Narrative Open Epigenetics Open Article Page