Gut Microbes • Vol 17 • No 1
<i>APOE4</i> genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes
2025
<i>APOE4</i>, a key risk factor for Alzheimer's disease, influences gut microbiota and microbial metabolites (e.g. amino acids and dietary fiber (DF) derived short-chain fatty acids (SCFAs)). However, its role in modulating microbiota-driven DF metabolism and its effect on cognitive status remains unclear. This cross-sectional study (<i>n</i> = 170) investigates the association between <i>APOE4</i> genotype, DF consumption, and metabolism in individuals with subjective cognitive impairment (SCI) and mild cognitive…