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Hierarchy
Briefings in Bioinformatics • Vol 25 • No 4
Comprehensive single-cell RNA-seq analysis using deep interpretable generative modeling guided by biological hierarchy knowledge
2024
Abstract Recent advances in microfluidics and sequencing technologies allow researchers to explore cellular heterogeneity at single-cell resolution. In recent years, deep learning frameworks, such as generative models, have brought great changes to the analys…
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Hierarchy

System of elements that are subordinated to each other

A hierarchy (from Greek: ἱεραρχία, hierarkhia , 'rule of a high priest', from hierarkhes , 'president of sacred rites') is an arrangement of items (objects, names, values, categories, etc.) that are represented as being "above", "below", or "at the same level as" one another. Hierarchy is an important concept in a wide variety of fields, such as architecture, philosophy, design, mathematics, computer science, organizational theory, systems theory, systematic biology, and the social sciences (especially political science).

A hierarchy can link entities either directly or indirectly, and either vertically or diagonally.

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Briefings in Bioinformatics • Vol 25 • No 4
Comprehensive single-cell RNA-seq analysis using deep interpretable generative modeling guided by biological hierarchy knowledge
2024
Abstract Recent advances in microfluidics and sequencing technologies allow researchers to explore cellular heterogeneity at single-cell resolution. In recent years, deep learning frameworks, such as generative models, have brought great changes to the analysis of transcriptomic data. Nevertheless, relying on the potential space of these generative models alone is insufficient to generate biological explanations. In addition, most of the previous work based on generative models is limited to shallow neural network…
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Computer Science
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Economics