main webpage W Topic Hudson Yards (Development) Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein 2024 Abstract Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding goal. This wo… Article Open Hudson Yards (Development) Open Article Page

Hudson Yards (Development)

Development project in Manhattan, New York Hudson Yards is a 28-acre (11 ha) real estate development in the Hudson Yards area of Manhattan, New York City, between the Chelsea and Hell's Kitchen neighborhoods. Upon completion, 13 of the 16 planned structures on the West Side of Midtown South would sit on a platform built over the West Side Yard, a storage yard for Long Island Rail Road trains. The first of its two phases, opened in 2019, comprises a public green space and eight structures that contain residences, a hotel, office buildings, a mall, and a cultural facility. The second phase, on which construction had not started as of 2022, will include residential space, an office building, and a school. Critical Symbolic Virtual Narrative Open Hudson Yards (Development) Open Article Page

Exploring foci of: Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein 2024 Abstract Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding goal. This work explores the suitability of a pyridothiophene scaffold for α‐syn PET radiotracers, where 47 derivatives of a potent pyridothiophene (asyn‐44; K d =1.85 nM) were synthesized and screened against [ 3 H]asyn‐44 in competitive binding assays using post‐mortem P… Open Article Page

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Explore Hudson Yards (Development) W Topic Hudson Yards (Development) Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein 2024 Abstract Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding goal. This wo… Article Critical Symbolic Virtual Narrative Open Hudson Yards (Development) Open Article Page