Prenylated flavins: structures and mechanisms Article Swipe
Related Concepts
Samuel Bloor
,
Iaroslav Michurin
,
Gabriel R. Titchiner
,
David Leys
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/febs.16371
· OA: W4206970408
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/febs.16371
· OA: W4206970408
The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX. A detailed picture of the biochemistry of flavin prenylation, oxidative maturation, and covalent catalysis underpinning reversible decarboxylation is emerging. This reveals the prFMN cofactor can undergo a wide range of transformations, complemented by considerable UbiD‐variability. These provide a blueprint for biotechnological applications aimed at producing hydrocarbons or aromatic C–H activation through carboxylation.
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