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Metabolic Pathway
PLoS Computational Biology • Vol 15 • No 1
A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types
2019
S. aureus is classified as a serious threat pathogen and is a priority that guides the discovery and development of new antibiotics. Despite growing knowledge of S. aureus metabolic capabilities, our understanding of its systems-level responses to different m…
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Metabolic Pathway

Linked series of chemical reactions occurring within a cell

In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reactions catalyzed by enzymes.: 26 In most cases of a metabolic pathway, the product of one enzyme acts as the substrate for the next. However, side products are considered waste and removed from the cell. These enzymes often require dietary minerals, vitamins, and other cofactors to function.

Different metabolic pathways function in the position within a eukaryotic cell and the significance of the pathway in the given compartment of the cell.

Exploring foci of:
PLoS Computational Biology • Vol 15 • No 1
A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types
2019
S. aureus is classified as a serious threat pathogen and is a priority that guides the discovery and development of new antibiotics. Despite growing knowledge of S. aureus metabolic capabilities, our understanding of its systems-level responses to different media types remains incomplete. Here, we develop a manually reconstructed genome-scale model (GEM-PRO) of metabolism with 3D protein structures for S. aureus USA300 str. JE2 containing 854 genes, 1,440 reactions, 1,327 metabolites and 673 3-dimensional protein …
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Staphylococcus Aureus
Biology
Computational Biology
Metabolomics
Biochemistry
Bacteria
Bioinformatics