Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing Article Swipe

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Lucie Desmoulins , Chloé Chrétien , Romain Paccoud , Stephan C. Collins , Céline Cruciani‐Guglielmacci , Anne Galinier , Fabienne Liénard , Aurore Quinault , Sylvie Grall , C. Allard , Claire Fenech , Lionel Carneiro , Thomas Mouillot , Audren Fournel , Claude Knauf , Chr̀istophe Magnan , Xavier Fioramonti , Luc Pénicaud , Corinne Leloup ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1016/j.molmet.2018.11.007

A hypothalamic alteration of DRP1-induced fission and mROS signaling in response to glucose was observed in HGS-induced IS of rats exposed to a 3 week HFHS diet. Early hypothalamic modifications of the neuronal activity could participate in a primary defect of the control of IS and ultimately, the development of diabetes.

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Internal medicine Endocrinology DNM1L Mitochondrial fission AMPK Insulin Glucose homeostasis Carbohydrate metabolism Chemistry Glucose uptake Mitochondrion Biology Medicine Cell biology Insulin resistance Protein kinase A Phosphorylation

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.molmet.2018.11.007
PDF: https://www.sciencedirect.com/science/article/am/pii/S2212877818310937?via%3Dihub
OA Status: gold
Cited By: 18
References: 62
Related Works: 10
OpenAlex ID: https://openalex.org/W2903402019

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