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Mycobacterium Avium-Intracellulare Infection
bioRxiv (Cold Spring Harbor Laboratory)
Fighting <i>Aspergillus</i> infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting
2025
Abstract Aspergillus fungi are opportunistic pathogens that affect millions of people worldwide. Aspergilli produce organic acids to optimize the environmental pH and match the needs of their enzymatic machinery. In this study, we tested the hypothesis that t…
Article

Mycobacterium Avium-Intracellulare Infection

Medical condition

Mycobacterium avium-intracellulare infection ( MAI ) is an atypical mycobacterial infection, i.e. one with nontuberculous mycobacteria or NTM, caused by Mycobacterium avium complex (MAC), which is made of two Mycobacterium species, M. avium and M. intracellulare. This infection causes respiratory illness in birds, pigs, and humans, especially in immunocompromised people. In the later stages of AIDS, it can be very severe. It usually first presents as a persistent cough. It is typically treated with a series of three antibiotics for a period of at least six months.

M. avium , M. intracellulare , and M.

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bioRxiv (Cold Spring Harbor Laboratory)
Fighting <i>Aspergillus</i> infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting
2025
Abstract Aspergillus fungi are opportunistic pathogens that affect millions of people worldwide. Aspergilli produce organic acids to optimize the environmental pH and match the needs of their enzymatic machinery. In this study, we tested the hypothesis that this also occurs during infection. By producing oxalic acid (OA), Aspergillus would manipulate pH during lung infection and thus, interfering with this process could control the pathogen. To test this hypothesis, we assessed in silico the potential for OA produ…
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