Chemistry - A European Journal • Vol 31 • No 38
Convergent Approach Toward ADP‐Ribosylated Peptides via a Chemoselective Phosphate Condensation
2025
Abstract The preparation of well‐defined ADP‐ribosylated peptides is essential for studying the functional implications of this post‐translational modification. While methodologies exist for the chemical synthesis of short oligo‐ADPr fragments and mono‐ADP‐ribosylated peptides separately, combining the two distinct chemistries, required to assemble them, has remained challenging. In this research, we employ a methodology for the regio‐ and chemoselective condensation of two phosphomonoesters to convergently instal…