A Case of Large Cell Neuroendocrine Carcinoma of the Bladder With Long‐Term Control by Metastasectomy

Naoto Takaoka , Kosuke Kobayashi , Tetsumi Yamane , Kazuma Hiramatsu , Kazunari Tsuchihashi , Hiroaki Kawanishi , Hiroyasu Yamashiro , Tomitaka Nakayama , Kazuhiro Okumura ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1002/iju5.70102

Introduction Large cell neuroendocrine carcinoma (LCNEC) of the bladder is rare and aggressive. Reports of metastasectomy for single distant metastases are even rarer. Case Presentation A 49‐year‐old man was admitted to our hospital with gross hematuria. Cystoscopy, magnetic resonance imaging, and computed tomography revealed invasive bladder cancer without metastasis. He underwent transurethral resection of the bladder tumor, and histopathological examination confirmed LCNEC. The patient received neoadjuvant chemotherapy followed by partial cystectomy. Nineteen months postoperatively, a solitary metastasis was detected in the right axillary lymph node, and at 44 months, another solitary metastasis appeared in the subcutaneous tissue outside the right scapula. Both metastases were surgically resected, and no additional treatment was administered. At the time of this writing, there had been no recurrence or metastasis for 42 months following the second metastasectomy. Conclusion Metastasectomy may be an effective treatment option for solitary metastasis of LCNEC of the bladder.