Figure 5 from Structurally Oriented Classification of <i>FOXA1</i> Alterations Identifies Prostate Cancers with Opposing Clinical Outcomes and Distinct Molecular and Immunologic Subtypes

Justin H. Hwang , Pornlada Likasitwatanakul , Sachin Kumar Deshmukh , Sharon Wu , Jason J. Kwon , Eamon Toye , David Moline , Mark G. Evans , Andrew Elliott , Rachel Passow , Christine Luo , Emily John , Nishant Gandhi , Rana R. McKay , Elisabeth I. Heath , Chadi Nabhan , Natalie Reizine , Jacob J. Orme , Josep Domingo‐Domenech , Oliver Sartor , Sylvan C. Baca , Scott M. Dehm , Emmanuel S. Antonarakis ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.28523103

Molecular associations by FOXA1 alteration class. Percentages of (A) TMPRSS2–ERG fusions, (B) TP53 mutations, (C) MSI-high status, and (D) TMB-high status based on FOXA1 alteration classes. All q values are relative to WT cases. Percentages of select genetic alterations comparing WT and (E) class 1B, (F) class 1C, (G) class 2, (H) and class 3A. *, q value < 0.05; **, q value < 0.01; ***, q value < 0.001; ****, q value < 0.0001. I, Heatmaps are organized by hallmark pathways that are significantly enriched (FDR <0.05) in class 1B and 2 in which normalized enrichment scores are depicted. *, FDR < 0.05; **, FDR < 0.01; ***, FDR < 0.001; ****, FDR < 0.0001. HRR, homologous recombinant repair genes; ns, nonsignificant.