main webpage
W Topic
Targeted Killing
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1
2022
Targeted protein degradation induced by heterobifunctional compounds and molecular glues presents an exciting avenue for chemical probe and drug discovery. To date, small-molecule ligands have been discovered for only a limited number of E3 ligases, which is …
Article

Targeted Killing

Removal of enemy combatants by governments against enemy forces.

Targeted killing is a form of assassination carried out by governments outside a judicial procedure or a battlefield.

Since the late 20th century, the legal status of targeted killing has become a subject of contention within and between various nations. Historically, at least since the mid-eighteenth century, Western thinking has generally considered the use of assassination as a tool of statecraft to be illegal. Some academics, military personnel and officials describe targeted killing as legitimate within the context of self-defense, when employed against terrorists or combatants engaged in asymmetrical warfare.

Exploring foci of:
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1
2022
Targeted protein degradation induced by heterobifunctional compounds and molecular glues presents an exciting avenue for chemical probe and drug discovery. To date, small-molecule ligands have been discovered for only a limited number of E3 ligases, which is an important limiting factor for realizing the full potential of targeted protein degradation. We report herein the discovery by chemical proteomics of azetidine acrylamides that stereoselectively and site-specifically react with a cysteine (C1113) in the E3 l…
Click Targeted Killing Vs:
Cd40 (Protein)
Protein–Protein Interaction
Ki-67 (Protein)
Sumo Protein
Protein Kinase B
Transmembrane Protein
Soy Protein
G Protein
Protein Structure Prediction
Click Targeted Killing Vs:
Protein Kinase
14-3-3 Protein
Protein Folding
Snare Protein
Targeted Advertising
Protein