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Thyroid Cancer
Frontiers in Oncology • Vol 15
Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose
2025
Objective This study aims to investigate the influence of intrafraction DNA damage repair on biologically effective dose (BED) in Ir-192 high-dose-rate (HDR) brachytherapy (BT) for cervical cancer. Specifically, we examine BED variations resulting from source…
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Thyroid Cancer

Malignancy originating in the thyroid gland

Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck, difficulty swallowing or voice changes including hoarseness, or a feeling of something being in the throat due to mass effect from the tumor. However, most cases are asymptomatic. Cancer can also occur in the thyroid after spread from other locations, in which case it is not classified as thyroid cancer.

Risk factors include radiation exposure at a young age, having an enlarged thyroid, family history and obesity.

Exploring foci of:
Frontiers in Oncology • Vol 15
Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose
2025
Objective This study aims to investigate the influence of intrafraction DNA damage repair on biologically effective dose (BED) in Ir-192 high-dose-rate (HDR) brachytherapy (BT) for cervical cancer. Specifically, we examine BED variations resulting from source decay at various treatment time points across different tumor cell lines and normal tissues. Methods Instead of the simplified BED formula, which does not account for intrafraction and interfraction repair or tumor repopulation, we applied the generalized BED…
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