Personalised Bacteriophage-enriched Faecal Microbiota Transplantation: A Precision Microbiome Modulation Therapy for Helicobacter pylori Eradication Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.4103/atmr.atmr_105_25
· OA: W4415742035
Background: To address the disadvantages associated with traditional antibiotic treatments, we propose a precision microbiome modulation therapy which combines curated faecal microbiota transplantation (FMT) with particular bacteriophage (phage) for Helicobacter pylori eradication. Methods: The phage component was designed to ensure high lytic efficiency and specificity against H. pylori while minimizing resistance development. The FMT formulation has been thoroughly investigated for stability and microbial variety, and its compatibility has been proven ex vivo for maintaining ecological balance. The suggested strategy substitutes broad-spectrum antibiotics by a synergistic phage-FMT combination to enhance stomach survival. This type of procedure can be performed with enteric-coated capsules or endoscopically. Real-time polymerase chain reaction monitors the success rate of therapy through evaluation of microbiota restoration indications and eradication efficiency. Precision microbiome engineering has improved significantly because of the treatment’s utilisation of anaerobic bioreactors for FMT processing and high-throughput microfluidics for phage isolation. Results: By carefully managing H. pylori and restoring a robust gut microbiota, the dual-action strategy decreases the adverse effects and recurring risks. Conclusion: Clinical validation provides a sustainable substitute for antibiotic-dependent methods by emphasising pathogen removal and ecological healing. This strategy addresses antibiotic resistance and applies ecological and precision medicine principles to improve H. pylori management.
