Argonaute
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Description
The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, plays a central role in RNA silencing processes as essential components of the RNA-induced silencing complex (RISC). RISC is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi- interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage, translation inhibition, and/or the initiation of mRNA decay.
The name of this protein family is derived from a mutant phenotype resulting from mutation of AGO1 in Arabidopsis thaliana , which was likened by Bohmert et al. to the appearance of the pelagic octopus Argonauta argo.
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- Slug: argonaute
- Added: Jul 20, 2024