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Denis Noble (born 16 November 1936) is a British physiologist and biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed professor emeritus and co-director of computational physiology. He is one of the pioneers of systems biology and developed the first viable model of the working heart in 1960.
In 2014, Noble established The Third Way of Evolution (TWE) project with James A. Shapiro which rejects natural selection as the primary cause of evolution and predicts that the entire framework of the modern synthesis of evolution will be replaced, though these claims have not gained support from mainstream evolutionary biology, and TWE has been described as a "fringe movement".
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